Multiple Choice Questions on Antibodies

1. Antibodies are

a) proteins
b) glycoproteins
c) carbohydrates
d) nucleic acid

2. Antibodies consists of

Antibody

a) 2 light chains and 2 heavy chains arranged in a Y-shaped configuration
b) A light chain and 2 heavy chains arranged in a Y-shaped configuration
c) 2 light chains and a heavy chain arranged in a Y-shaped configuration
d) all of these

3. Light chains and heavy chains are joined by

a) covalent bond
b) hydrogen bond
c) di-sulphide bond
d) ionic bond

4. The antigen binding site on an antibody is called

a) antitope
b) epitope
c) paratope
d) endotope

5. An antibody has

a) 2 Fab regions and an Fc region
b) an Fab region and an Fc region
c) 2 Fab regions and 2 Fc regions
d) many Fab regions and many Fc regions

6. The hypervariable region resides in the

a) N terminal region of light chain
b) N-terminal region of light and heavy chain
c) C-terminal region of light chain
d) C-terminal region of light chain and heavy chain

7. Fab stands for

a) fragment antibody binding
b) fragment antigen binding
c) fragment antibody or antigen binding
d) fragment affinity binding

 

8. Which of the following statement is true regarding Fc region

a) fragment crystalisation and is the constant region
b) fragment constant and is the variable region
c) fragment crystalisation and is the variable region
d) fragment crystalisation and has both variable and constant region

9. Fab region

a) has a hypervariable region that binds with antibody
b) has a hypervariable region that binds with antigen
c) has a hypervariable region that binds with other immune cells
d) all of these

10. Fc region is involved in

a) cell surface receptor binding
b) complement activation
c) determining diffusivity of antibody molecule
d) all of these

11. The ability of antigen to stimulate antibody production is called

a) affinity
b) Antigenicity
c) elicitation
d) none of these

12. Light chains and heavy chains of antibodies are joined by

a) hydrogen bond
b) hydrophobic bond
c) di-sulphide bond
d) ionic bond

13. Clearance of antigens by antibodies involve

a) neutralization and agglutination
b) opsonisation and complement activation
c) precipitation
d) all of these

14. The two identical light chains of an antibody belongs to

a) kappa only
b) lambda only
c) lambda or kappa
d) none of these

15. The hypervariable region of antibody consists of

a) 5-10 aminoacids that form antigen binding site
b) 50-100 aminoacids that form antigen binding site
c) 5-10 aminoacids that forms the antibody binding site
d) a part of constant region of heavy and light chain

 

Learn more: * Immunology Notes * Immunology MCQs 
Answers
1. b) glycoproteins
2. a) 2 light chains and 2 heavy chains arranged in a Y-shaped configuration
3. c) di-sulphide bond
4. c) paratope
5. a) 2 Fab regions and an Fc region
6. b) N-terminal region of light and heavy chain
7. b) fragment antigen binding
8. a) fragment crystalisation and is the constant region
9. b) has a hypervariable region that binds with antigen
10. d) all of these
11. b) Antigenicity
12. c) di-sulphide bond
13. d) all of these
14. a) kappa only
15. a) 5-10 aminoacids that form antigen binding site