MCQ on Molecular Evolution

 1. Whose name is most closely associated with molecular evolution?

a) Theodosius Dobzhansky 

b) Motoo Kimura

c) Frederick Sanger 

d) Stephen Jay Gould



2. Which one of the following statements is NOT TRUE about the Neutral Theory as proposed by Motoo Kimura?

a) Except for advantageous mutations, most alleles are under neutral selection

b) The rate of evolution for most genes will be equal to the neutral mutation rate

c) Advantageous mutations are exceedingly rare

d) At the level of DNA sequences, genetic drift dominates the evolution


MCQ on Molecular Evolution

3. Which of the following is a prediction of the neutral theory of molecular evolution that is supported by data? 

a) Human and chimps differ more in DNA sequences of pseudogenes than in coding regions of functional genes

b) Human and chimps differ more in DNA sequences of coding regions of functional genes than ot pseduogenes

c) Human have a faster evolution of most of their DNA sequences than chimps

d) The more advanced species have more number of functional genes

 

4. If the ratio of the number of non-synonymous to synonymous substitutions per site in protein-coding gene is greater than one, it is an evidence of selection that is

a) positive.

b) negative.

c) neutral.

d) random.

 

5. Similarities in sequence and function of two proteins indicate that they are members of a family that share a Common ancestor. f they are from different species, they are called 

a) homologs.

b) orthologs

c) paralogs.

d) proteologs.

 

6. Mayfair genes (HYPOTHETICAL) consist of a superfamily of transcription factors. They are found in 4 clusters in mammals in 2 clusters in insects;and in a singie ciuster in an ancestor to insects. These data consistent with all of the following explanations EXCEPT: (DEC 2016)

a) Two successive genome duplication event occurred between ancestral organisms and vertebrates

b) the first duplication may have taken place before divergence of vertebrates

c) exon shuffling exclusively produced such cluster

d)whole-genome duplication could lead to such observation.

 

7. The most commonly used molecular tool for phylogentic analysis involves sequencing of 

a) mitochondrial DNA

b) mitochondrial RNA.

c) ribosomal RNA

d) nuclear DNA

 

8.  Which species concept utilizes morphological molecular characters to distinguish between species?

a) Evolutionary

b) Ecological

c) Biological

d) Phylogenetic

 

9. For which, of the following characters, convergent evolution is most unlikely? following

a) Locomotor organs.

b) Secondary metabolites.

c) Conditionally expressed genes

Biological

 

10. Evolution of multi-gene family occurs by 

a) only gene duplication.

b)  both duplication and unequal crossing over 

c) random mutations

d) only unequal crossing-over

Learn more: Quiz on Evolution - The origin of Life

Answers:

1. b) Motoo Kimura

2. a) Except for advantageous mutations, most alleles are under neutral selection

3. a) Human and chimps differ more in DNA sequences of pseudogenes than in coding regions of functional genes

4. a) positive.

5. b) orthologs

6. c) exon shuffling exclusively produced such cluster

7. a) mitochondrial DNA / d) nuclear DNA

8. d) Phylogenetic

9.  d) base sequence of a gene.

10. b) both duplication and unequal crossing over

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