Biology Multiple Choice Questions and Answers for Different Competitive Exams

MCQ on Immunology -Complement system

complement system
Complement system
a) consists of 20 serum proteins
b) serum proteins acts as biological cascade
c) both a and b
d) are set of antibodies
2. Complement system is involved in
a) specific defence
b) non-specific defence
c) both a and b
d) none of these
3. Which of the following statements are true regarding complement activation
a) lysis of pathogen, tumor cells and allografts
b) production of mediators that attracts neutrophils to the site of inflammation
c) opsonization
d) all of these
4. Classical pathway of complement system is activated by
a) antibody-antigen complexes
b) antigen
c) antigenic peptides
d) antigens bound to MHC
5. Alternate pathway of complement system is activated by
a) antibody-antigen complexes
b) antigen
c) microorganisms or its toxins
d) antigens bound to MHC
6. Classical pathway of complement system is involved in
a) specific defence
b) adaptive immunity
c) both a and b
d) non-specific defence
7. Alternate pathway of complement system is involved in
a) non-specific defence
b) innate immunity
c) both a and b
d) adaptive immunity
8. Which of the following is the central molecule in complement pathway
a) C1
b) C2
c) C3b
d) C5
9. Cell lysis in complement pathway is initiated by
a) membrane destruction complex
b) membrane degradation complex
c) membrane attacking complex
d) membrane lysis complex
10. MAC is
a) C5b6789 complex
b) C5b5678 complex
c) C5b5789 complex
d) Protein polysaccharide complex
11. Which of the following is required for C1 activation
a) Ca
b) Mg
c) Mn
d) Zn
12. Which of the following is the most potent anaphylatoxin
a) C3a
b) C4a
c) C5a
d) C1
13. In alternate pathway
a) factor b is involved
b) factor d is involved
c) both a and b
d) Only factor f is involved
14. Biological role of complement system include
a) cytolysis and chemotaxis
b) opsonisation
c) anaphylotoxin and enhanced antibody production
d) all of these
15. Body’s own cells are protected from membrane attack complex by a surface glycoprotein called
a) MHC
b) DAF
c) TCR
d) BCR
Answers:
1. c) both a and b
2.c) both a and b
3. d) all of these
4. a) antibody-antigen complexes
5. c) microorganisms or its toxins
6. c) both a and b
7. c) both a and b
8. c) C3b
9. c) membrane attacking complex
10. a) C5b6789 complex
11. a) Ca
12. c) C5a.( Anaphylotoxins: induces the release of inflammatory mediators like histamines from the mast cells. C3a, C4a and C5a are the anaphylatoxins of which C5a is the most potent)
13. c) both a and b
14. d) all of these
15. b) DAF (Human cells have a glycoprotein situated on the cell surface called as decay accelerating factor (DAF). DAF prevents the formation of membrane attack complex by destabilizing C3 and C5 convertase.)

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