Biology Multiple Choice Questions and Answers for Different Competitive Exams

Multiple Choice Questions on Gene Therapy

1. Gene therapy in humans was first practised by Blease and Andresco to cure
a) cystic fibrosis
b) Hemophilia
c) Thalassemia
d) Severe combined immunodeficiency disease
2. Gene therapy is 
gene therapy
Gene Therapy- How it works?
a) method aim to cure genetic disorders
b) method to provide correct version of the defective gene
c) method to replace a defective gene with a healthy gene
d) all of the above
3. If the remedial gene does the function of defective gene. The approach is called as
a) gene replacement therapy
b) gene augmentation therapy
c) both a and b
d) Corrective gene therapy
4. The introduction of remedial gene to bone marrow cells comes under
a) germ line therapy
b) somatic cell therapy
c) both a and b
d) Corrective gene therapy
5. The possibility of introducing correct version of the defective gene in all cells of the individual is achieved by
a) germ line therapy
b) somatic cell therapy
c) gene augmentation therapy
d) Corrective gene therapy
6. Introduction of healthy gene into cells, tissues or organs cultured in vitro and reimplanting back to the patient is referred as
a) germ line therapy
b) somatic cell therapy
c) ex vivo therapy
d) in vivo therapy
7. Somatic cell therapy include
a) ex vivo therapy
b) in vivo therapy
c) antisense therapy
d) all of these
8. Embryo therapy was devised by Handyside et al to cure
a) Cystic fibrosis
b) Hemophilia
c) Thalassemia
d) Severe combined immunodeficiency disease
9. Introduction of healthy gene at specific sites to displace the defective gene is referred as
a) germ line therapy
b) somatic cell therapy
c) both a and b
d) Corrective gene therapy
10. The common gene delivery system for In vivo gene therapy is
a) micro injection
b) lipofecction
c) Adeno viral vectors
d) electroporation
11. The method of treating genetic diseases by introducing a remedial gene that prevents the expression of a specific defective gene is
a) ex vivo therapy
b) in vivo therapy
c) antisense therapy
d) all of these
12. Ex vivo therapy includes
a) bone marrow transplantation
b) liver transplantation
c) kidney transplantation
d) all of these
13. Which of the method is useful especially in the treatment of cancer
a) ex vivo therapy
b) in vivo therapy
c) antisense therapy
d) all of these
14. Which of the statement is false regarding gene augmentation therapy
a) suitable for single gene disorders
b) random insertion of healthy gene
c) suitable for multi gene disorders also
d) no recombination event is required
15. Which of the following is most controversial approach in gene therapy
a) germ line therapy
b) somatic therapy
c) ex vivo therapy
d) anti sense therapy
Answers 
1. d) Severe combined immunodeficiency disease
2. d) all of the above
3. c) both a and b
4. b) somatic cell therapy
5. a) germ line therapy
6. c) ex vivo therapy
7. d) all of these
8. a) Cystic fibrosis
9. d) Corrective gene therapy
10. c) Adeno viral vectors
11.c) antisense therapy
12. d) all of these
13. c) antisense therapy
14. c) suitable for multi gene disorders also
15. a) germ line therapy
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