Multiple Choice Questions on Genetics

1. Which among the following is not a model organism in genetic analysis?

a) The Zebra fish

b) The plant Arabidopsis thaliana

c) The mouse deer

d) The nematode Caenorhabditis elegans

2. Down syndrome is usually the result of an extra chromosome ---, so that each body cell has a total of 47 chromosomes.

a) 18

b) 19

c) 20

d) 21

3. A gene showing codominanace

a) Has one allele dominant to the other

b) Has both alleles independently expressed in the heterozygote

c) Has alleles tightly linked on the same chromosome

d) Has alleles expressed at the same time in development

4. X chromosome inactivation

a) Normally takes place in males but not females

b) Is the causes of the y chromosome being genetically inactive

c) Takes place in humans so that the same X chromosome is inactive in all of the cells of a female

d) Results in genetically turning off one of the two X chromosomes in female mammals

5. Positional cloning refers to

a) Using a selection procedure to clone a cDNA

b) Cloning a portion of a gene using PCR

c) Isolating a gene by PCR using primers from another species

d) Mapping a gene to a chromosomal region and then identifying and cloning a genomic copy of the gene from the region

6. Which of the following is not a property of the genetic code?

a) Non overlapping

b) Almost universal

c) Four stop codons

d) Redundant

7. Which of the following conditions is caused by trinucleotide (triplet) repeat expansion?

a) Cystic fibrosis

b) Duchenne muscular Dystrophy

c) Huntington disease

d) Osteogenesis imperfeca

8. In DNA, adenine normally pairs with

a) Cytosine

b) Guanine

c) Thymine

d) Uracil

9. The Nobel prize in Physiology or Medicine 1962 was awarded jointly to Francis Harry Compton Crick, James Dewey Watson and ----“ for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material”

a) Rosalind Franklin

b) Maurice High Frederick Wilkins

c) Erwin Chargaff

d) Frederick Sanger

10. Which of the following pairs of base sequence could form a short stretch of a normal double helix of DNA?

a) 5’-AGCT-3’ With 5’TCGA-3’

b) 5’-AATT-3’ With 5’TUAA-3’

c) 5’-GCGC-3’ With 5’TATA-3’

d) 5’-ATGC-3’ With 5’GCAT-3’

Learn more: MCQ on Genetics
Answers

1. c) The mouse deer
2. d) 21
3. b) Has both alleles independently expressed in the heterozygote
4. d) Results in genetically turning off one of the two X chromosomes in female mammals
5. d) Mapping a gene to a chromosomal region and then identifying and cloning a genomic copy of the gene from the region
6. c) Four stop codons
7. c) Huntington disease
8. c) Thymine
9. b) Maurice High Frederick Wilkins
10. d) 5’-ATGC-3’ With 5’GCAT-3’