Multiple Choice Questions on p53 Tumour Suppressor Gene

1. p53 stands for

a) protein with 53 aminoacids
b) protein coded by gene of 53 nucleotides
c) protein of 53 kilo dalton molecular size
d) protein discovered in 1953

2. p53 is

a) an oncogene
b) a cytotoxic protein
c) a tumor suppressor protein
d) all of the above

3. The p53 concentration in the normal cell is regulated by
a) BAX
b) Apaf-1
c) Mdm2
d) P21

4. Which of the following statement is correct
a) The level of p53 in normal cell is high
b) DNA damage is due to low level of p53
c) The level of p53 in the normal cell is low
d) High level of p53 in normal cell prevent apoptosis

5. P53 is called as the ‘guardian of the genome’ as
a) It prevents genome mutation
b) It kills tumor cells
c) It protects genome from DNA damaging chemicals
d) All of these

6. p53 is activated by
a) Phosphorylation
b) Dephosphorylation
c) Methylation
d) carboxylation

7. Which of the following genes are activated by p53
a) BAX and p21
b) GAAD45 and BAX
c) BAX , Apaf-1 and p21
d) All of these

8. p21, the protein activated by p53 on DNA damage is a
a) Cyclin inhibitor
b) Cdk inhibitor
c) Proapoptotic protein
d) Anti apoptotic protein

9. BAX gene activation by p53 is in response to
a) DNA damage
b) Cell stress
c) Irreparable DNA damage
d) Reparable DNA damage

10. p53 gene is located on
a) 14^th chromosome
b) 15^th chromosome
c) 16^th chromosome
d) 17^th chromosome
Learn more:

• Multiple Choice Questions on Cancer
• Multiple Choice Questions on Biotechnology
• Multiple Choice Questions on Human Biology
• Videos on P53

Answers
1. c) protein of 53 kilo dalton molecular size
2. c) a tumor suppressor protein
3. c) Mdm2
4. c) The level of p53 in the normal cell is low
5. a) It prevents genome mutation
6.  a) Phosphorylation
7.  d) All of these
8.  b) Cdk inhibitor
9.  c) Irreparable DNA damage
10. d) 17^th chromosome