Multiple Choice Questions on Human Genetic Disorders

1. Down’s syndrome is characterised by

a) 19 trisomy
b) 21 trisomy
c) only one X chromosome
d) two X and one Y chromosome

2. Which of the following is known as Royal disease?
a) Sickle cell anaemia
b) Haemophilia
c) Alzheimer’s disease
d)  Colour blindness

3. Patau’s syndrome occurs due to
a) trisomy of 13^th chromosome
b) trisomy of 18^th chromosome
c) trisomy of 21^st chromosome
d)  trisomy of 22^nd chromosome

4. The most important example of point mutation is found in a disease called?
a) Thalassemia
b) Night blindness
c) Sickle cell anaemia
d)  Down’s syndrome

5. The syndrome in which individual somatic cell contains three sex chromosome XXX is called
a) Down’s syndrome
b) Super female
c) Turner’s syndrome
d) Klinefelter’s syndrome
 
6. Identify a Mendelian disorder from the following
a) Down’s syndrome
b) Klinefelter’s syndrome
c) Turner’s syndrome
d) Phenylketonuria

7. A man has enlarged breasts, spare hair on body and sex complement as XXY. He suffers from
a) Down’s syndrome
b) Klinefelter’s syndrome
c) Turner’s syndrome
d) Edward’s syndrome

8. In a family, father is having a disease and mother is normal. The disease is inherited to only daughters and not to the sons. What type of disease is this?
a) Sex linked dominant
b) Sex linked recessive
c) Autosomal dominant
d) Autosomal recessive

9. In man, which of the following genotypes and phenotypes may be the correct result of aneuploidy in sex chromosomes?
a) 22 pairs + Y females
b) 22 pairs + XX females
c) 22 pairs + XXY males
d) 22 pairs + XXXY females

10. A woman with one gene for haemophilia and one gene for color blindness on one of the X chromosomes marries a normal man. How will the progeny be?
a) Haemophilic and colour blind daughters
b) All sons and daughters are haemophilic and colour blind
c) 50% haemophilic and colour blind sons and 50% normal sons
d)  50% haemophilic colour blind sons and 50% colour blind daughters
Learn more:

• Multiple Choice Questions on Genetic Diseases
• Quiz on Human Genetic Disorder
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Answers:
1. b) 21 trisomy
2. b) Haemophilia
3. a) trisomy of 13^th chromosome
4. c) Sickle cell anaemia
5. b) Super female
6. d) Phenylketonuria
7. b) Klinefelter’s syndrome
8. a) Sex linked dominant
9. c) 22 pairs + XXY males
10. c) 50% haemophilic and colour blind sons and 50% normal sons