1. In animal
cell cultures, the addition of serum to media is essential for providing?
a) growth factors
b) amino acid for protein synthesis
c) nucleotide for DNA synthesis
d) all of these
2. cdc mutant
useful for the study of
a)various
stages of cell cycle
b)homeodomain
c)Apoptosis only
d)chromosome break point
3. Recombinant
DNA human health care product developed for treating haemophiliacs is
a) interferon
b) lymphokines
c) coaglutation
factor IX
d) phytohemaglutinin
4. Which of the
following has been produced commercially from mammalian culture?
a) insulin
b) renin
c) plasminogen
activator
d)antibacterial antibody
5. A
heterologous protein for its expression in the milk of a transgenic animal
should be under the control of the promoter of the gene coding for
a) preproinsulin
b) Lac Z
c)β globin
d) β lactoglobulin
6. Aminopterine
is used during the production of hybridoma cells because it
a) Blocks the
salvage pathway
b) Prevents the growth of B cells
c) Prevents the growth of myeloma cells
d) Blocks the synthesis of Ig by B cells
7. Antibody
diversity is generated by
a) Allelic
exclusion
b) Protein splicing
c) Somatic mutation
d) Interchromosomal recombination
8. Reverse
vaccinology indicates
a) from antibody to vaccine development
b) from genome sequence to vaccine development
c) from antigenic polysaccharide to vaccine
development
d) from
antigenic protein to vaccine development
9. The culture
fluid of 1000 to 5000 colonies of hybridoma are screened for monoclonal
antibody by
P- Antigen capture analysis Q- Western blot analysis
R-Northern blot analysis S-antibody capture analysis
a) P, Q
b) R, S
c) Q, S
d) P, S
10. All of the following are
produced by animal cells in culture and help the cells adhere to the culture
dish except
a) collagen
b) glycoprotein
c)
phospholipase A
d) hyaluronic acid
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Answers
1.a) growth factors
2. a)various stages of cell cycle
3. c) coaglutation factor IX
4. c) plasminogen activator
5. d) β lactoglobulin
6. a) Blocks the salvage pathway
7. a) Allelic exclusion
8. d) from antigenic protein to vaccine development
9. d) P, S
10. c) phospholipase A