Multiple Choice Questions on Mode of Action of Antibiotics

MCQ on Mode of Action of Antibiotics
1. Penicillin causes bacterial cell lyses by inhibiting the enzyme that catalyzes cross- linking of peptidoglycan chains of the bacterial cell wall. The enzyme is
a) enolpyruvyl transferase
b) transglycolase
c) transpeptidase
d) ribonuclease

2. Which of the following antibiotics blocks the first step of peptidoglycan cell wall synthesis by  inhibiting enzyme MurA?
a) Fosfomycin
b) Penicillin
c) Vancomycin
d) Bacitracin

3. Which of the following is a DNA gyrase inhibitor, thus disrupting bacterial DNA replication?
a) ciprofloxacin
b) Vancomycin
c) Chloramphenicol
d) Streptomycin

4. All the following drugs are bacterial cell wall synthesis inhibitors except
b) Bacitracin
c) Fosfomycin
d) Rifamycin

5. All the following are protein synthesis inhibitors which binds to the 50S ribosomal subunit and blocks protein synthesis except
a) Streptomycin
b) Erythromycin
c) Cliindamycin
d) Chloramphenicol

6. Which of the following antibiotic inhibits transcription by binding DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase?
b) Streptomycin
c) Carbenicillin
d) Actinomycin D

7. This antibiotic binds to the D-ala residues preventing cross linking of cell wall strands by preventing the binding of cross linking enzyme. The antibiotic is  
a) Erythromycin
b) Vancomycin
c) Cephalosporin

8. Which of the following is not a protein synthesis inhibitor by binding to 30 S small ribosomal subunit?
a) Kanamycin
b) Streptomycin
c) Erythromycin

9. Which of the following antibiotic prevents bacterial transcription by directly binding to the bacterial RNA polymerase?
a) Rifampin
b) polymixin
c) Puromycin
d) Streptomycin

10. The antibiotic that prevents peptidoglycan synthesis by blocking the transport of peptidoglycan monomer is
b) Cephalosporin
c) Bacitracin
 Learn more:
1. c) transpeptidase
2. a) Fosfomycin
3. a) ciprofloxacin
4. d) Rifamycin
5. a) Streptomycin
6. d) Actinomycin D
7. b) Vancomycin
8. c) Erythromycin
9. a) Rifampin
10. c) Bacitracin

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