1. Which among the following is not a model organism in genetic analysis?
a) The Zebra fishb) The plant Arabidopsis thalianac) The mouse deerd) The nematode Caenorhabditis elegans
2. Down syndrome is usually the result of an extra chromosome ---, so that each body cell has a total of 47 chromosomes.
a) 18b) 19c) 20d) 21
3. A gene showing codominanace
a) Has one allele dominant to the otherb) Has both alleles independently expressed in the heterozygotec) Has alleles tightly linked on the same chromosomed) Has alleles expressed at the same time in development
4. X chromosome inactivation
a) Normally takes place in males but not femalesb) Is the causes of the y chromosome being genetically inactivec) Takes place in humans so that the same X chromosome is inactive in all of the cells of a femaled) Results in genetically turning off one of the two X chromosomes in female mammals
5. Positional cloning refers to
a) Using a selection procedure to clone a cDNAb) Cloning a portion of a gene using PCRc) Isolating a gene by PCR using primers from another speciesd) Mapping a gene to a chromosomal region and then identifying and cloning a genomic copy of the gene from the region
6. Which of the following is not a property of the genetic code?
a) Non overlappingb) Almost universalc) Four stop codonsd) Redundant
7. Which of the following conditions is caused by trinucleotide (triplet) repeat expansion?
a) Cystic fibrosisb) Duchenne muscular Dystrophyc) Huntington diseased) Osteogenesis imperfeca
8. In DNA, adenine normally pairs with
a) Cytosineb) Guaninec) Thymined) Uracil
9. The Nobel prize in Physiology or Medicine 1962 was awarded jointly to Francis Harry Compton Crick, James Dewey Watson and ----“ for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material”
a) Rosalind Franklinb) Maurice High Frederick Wilkinsc) Erwin Chargaffd) Frederick Sanger
10. Which of the following pairs of base sequence could form a short stretch of a normal double helix of DNA?
a) 5’-AGCT-3’ With 5’TCGA-3’b) 5’-AATT-3’ With 5’TUAA-3’c) 5’-GCGC-3’ With 5’TATA-3’d) 5’-ATGC-3’ With 5’GCAT-3’
- c) The mouse deer
- d) 21
- b) Has both alleles independently expressed in the heterozygote
- d) Results in genetically turning off one of the two X chromosomes in female mammals
- d) Mapping a gene to a chromosomal region and then identifying and cloning a genomic copy of the gene from the region
- c) Four stop codons
- c) Huntington disease
- c) Thymine
- b) Maurice High Frederick Wilkins
- d) 5’-ATGC-3’ With 5’GCAT-3’
Learn more: MCQ on Genetics