Multiple Choice Questions on Molecular Basis of Inheritance

1. Which one of the following statement is wrong about Diplococcus pneumonia?
a) Inactivated R strains with inactivated S strains does not cause symptoms of disease.
b) Inactivated ‘S’ strains cause symptoms of disease
c) R strains with inactivated S strains cause symptoms of disease.
d) S strains with inactivated R strains cause symptoms of disease

2. For proving the semi conservative mode of replication of DNA E.coli, were first grown in the medium containing
a) 14NH3
b) (NH4 )2SO4
c) 15NH4Cl
d) 14NH4Cl

3. E.coli which was grown in the medium containing heavy isotope 15N for several generations is shifted to normal 14N medium, the percentage of DNA strands with 14N isotope after two generations is
a) 12.5 %
b) 50%
c)75%
d) 100%

4. In the above case the percentage of hybrid DNA after 3 generations is
a) 12.5 %
b) 25%
c) 75%
d) 50%

5. If 100 heavy DNA 15N15N are replicated three times in 14N medium, the result obtained is
a) 12.5% intermediate and 87.5% light DNA
b) 25% intermediate and 75 % light DNA
c) 50% heavy and 50% light DNA
d) 37.5 % half heavy and 62.5 heavy DNA

dna replication
a) Primed by RNA primer
b) formed 5’-3’ direction
c) United to form lagging strand
d) all of these

7. Which is wrong?
a) Alkaptonuria is due to a recessive gene
b) Gene controls in the metabolism
c) In eukaryotes DNA synthesis is faster than prokaryotes
d) Homogentisic acid is excreted in the urine in alkaptonuric patients.

8. The forms of Neurospora crassa which can grown in the minimal medium with additional nutrients is called
a) heterotroph
b) autotroph
c) Auxotroph
d) prototrophs

9. Difference between prokaryotic and eukaryotic ribosomes are due to
a) size
b) nucleotide
c) Sedimentation coefficients
d) Amount of RNA

10. The wrong statement is
a) Transcription occurs in the nucleus in prokaryotes
b) usually monocistronic mRNA is produced in Eukaryotes
c) In prokaryotes the primary mRNA transcript undergoes splicing
d) sigma subunit of RNA polymerase recognises the promoter

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Answers
1. b) Inactivated ‘S’ strains cause symptoms of disease
2. c) 15NH4Cl
3. c) 75%
4. b) 25%
   (In the third generation, total eight DNA molecules are formed. Two of them are hybrids ie
15N 14N 2/8 x100 =25%)
5. b) 25% intermediate and 75 % light DNA
6. d) all of these
7. c) In eukaryotes DNA synthesis is faster than prokaryotes
8. c) Auxotroph
9. c) Sedimentation coefficients
10. c) In prokaryotes the primary mRNA transcript undergoes splicing

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